HIGHLIGHTS
- who: August et al. from the The University of Tokyo, Japan have published the research: System level modeling and analysis of TNF- mediated sphingolipid signaling pathway in neurological disorders for the prediction of therapeutic targets, in the Journal: (JOURNAL)
- what: The authors assess the efficacy and potency of FDA-approved medicines, namely Etanercept, Nivocasan, and Scyphostatin, at later phases of neuronal inflammation by analyzing the model`s response to protein/ enzyme inhibition. An exemplar simulation run for the model shown in Supplementary Figure S2A is given in the Supplementary Figure S2B. The authors conducted two . . .
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