HIGHLIGHTS
- What: The authors aim to develop ex vivo models of human skin damaged by different treatments. The authors aim to systematically characterize the barrier integrity via an array of relevant parameters, such as the permeability, dermal absorption capacity, stratum corneum thickness and gene_expression of Frontiers in Medicine barrier function markers. The aim of this research was to establish reliable ex vivo models for compromised human skin, offering more ethical alternatives to animal models and aligning with the three Rs principles of replacement, reduction, and refinement in experimental research. Human-based ex vivo models developed in this study . . .
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