Systematic comparison of crispr-based transcriptional activators uncovers gene-regulatory features of enhancer-promoter interactions

HIGHLIGHTS

• who: Kaiyuan Wang et al. from the Department of Bioengineering, Rice University, Houston, TX, USA and , Department of BioSciences, Rice University, Houston, TX, USA have published the paper: Systematic comparison of CRISPR-based transcriptional activators uncovers gene-regulatory features of enhancer-promoter interactions, in the Journal: (JOURNAL)
• what: Collectively, the study provides new insights into the enhancer-mediated control of human gene_expression and the use of dCas9-based activators. Using several dCas9-based transcriptional activators, the authors demonstrate that the targeted activation of human eRNAs is positively correlated with mRNA synthesis from downstream promoters. The . . .
  

   

  

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