HIGHLIGHTS
SUMMARY
In renal cell carcinoma, TAMs are associated with tumor invasion, poor prognosis, angiogenesis, and immune escape (Kovaleva et_al, 2016; Fu et_al, 2019); therefore, MDGs as regulators of macrophage differentiation are probably used as biomarkers of ccRCC and potential prognostic indicators of malignant tumors. Overexpression of TIM-3/HAVCR2 is associated with poor prognosis in Frontiers in Genetics | www.frontiersin.org squamous cell carcinoma, colorectal, renal cell carcinoma, gastric, and breast cancers (Shen et_al, 2016; Wang et_al, 2016; Wang et_al, 2017; Stenzel, 2018). Studies have shown that the CD14 gene is related to macrophage differentiation . . .
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