Systematic investigation of the effects of multiple sv40 nuclear localization signal fusion on the genome editing activity of purified spcas9

HIGHLIGHTS

• who: Sailan Shui and colleagues from the Shanghai Institute for Advanced Immunochemical Studies, School of Life Science and Technology, Lausanne, Switzerland have published the Article: Systematic Investigation of the Effects of Multiple SV40 Nuclear Localization Signal Fusion on the Genome Editing Activity of Purified SpCas9, in the Journal: Bioengineering 2022, 83 of 24/08/2016
• what: The authors constructed and purified a set of Streptococcus pyogenes (SpCas9) variants containing one to four NLS repeats at the N- or C-terminus of the proteins and systematically analyzed the effects of multi-NLS fusion on the activity . . .
  

   

  

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