Systemic delivery of tnf-armed myxoma virus plus immune checkpoint inhibitor eliminates lung metastatic mouse osteosarcoma

HIGHLIGHTS

  • who: John D. Christie from the State University, Tempe, AZ, USA have published the paper: Systemic delivery of TNF-armed myxoma virus plus immune checkpoint inhibitor eliminates lung metastatic mouse osteosarcoma, in the Journal: (JOURNAL) of 22/09/2021
  • what: Of this study showed that the PBMC preloaded strategy was the most effective at reducing tumor burden and increasing median survival time but sequential intravenous multi-dosing with naked virus was comparably effective to a single infusion of PBMC-loaded virus. The authors explore the capacity of the systemic ex vivo delivery strategy of MYXV . . .

     

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