HIGHLIGHTS
SUMMARY
An area that relates closely to these domains is oxidative stress, where the production of Reactive Oxygen Species (ROS) during cellular respiration exceeds the antioxidant potential of a given biological system, thereby causing downstream modifications of crucial macromolecules such as proteins, lipids, and nucleic_acids. Given the established connections between psychopathology (including affective disorders), aging, and mortality, a characterization of antidepressant drug influence on levels of nucleic_acid damage from oxidation is clinically relevant. The analyses of the urinary nucleic_acid oxidation markers (in both patients and community control samples) were performed with ultra-performance liquid chromatography . . .
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