HIGHLIGHTS
SUMMARY
Epidemiological studies have identified associations of elevated systemic inflammation levels and worse cognition in cross-sectional studies, and a steeper cognitive decline in prospective studies. Anti-inflammatory therapy, particularly nonsteroidal anti-inflammatory drugs (NSAIDs), has been associated with a lower risk of cognitive decline in a meta-analysis of observational cohort studies. The authors leveraged a twosample MR to assess causality in relation to a comprehensive amount of 41 genetically predicted circulating levels of systemic inflammatory markers with general cognitive performance (with three additional domains of the fluid intelligence score, prospective memory result, and . . .
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