HIGHLIGHTS
- who: Linshan Shang and colleagues from the Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA have published the article: Systemic lipolysis promotes physiological fitness in Drosophila melanogaster, in the Journal: (JOURNAL)
- what: The authors show that overexpression of the cytosolic lipase bmm, which increased lipid catabolism, promoted numerous physiological parameters including fecundity, locomotion, oxidative metabolism, proteostasis, and resistance to thermal and ER stress . The study showed substantial induction of Hsp70 expression in bmm overexpression flies. This work provides additional rationale for pursuing therapeutic approaches, as done previously , that enhance lipolysis . . .
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