Systems modeling predicts that mitochondria er contact sites regulate the postsynaptic energy landscape

HIGHLIGHTS

• who: A. Leung from the (UNIVERSITY) have published the article: Systems modeling predicts that mitochondria ER contact sites regulate the postsynaptic energy landscape, in the Journal: (JOURNAL)
• what: The authors investigated the role of the ER, mitochondria, and MERC in modulating the spatiotemporal dynamics of calcium and localized ATP production in postsynaptic spines using computational modeling. In Supplemental Fig 2, the authors show that decreasing the diffusion coefficient by two orders of magnitude leads to a slight delay in cytosolic and mitochondrial ATP for dynamics (Supplemental Fig 2a, b). The model shows that the MERC . . .
  

   

  

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