T cell-independent eradication of experimental glioma by intravenous tlr7/8-agonist-loaded nanoparticles

HIGHLIGHTS

• who: Verena Turco from the (UNIVERSITY) have published the research work: T cell-independent eradication of experimental glioma by intravenous TLR7/8-agonist-loaded nanoparticles, in the Journal: (JOURNAL) of 24/01/2023
• what: The authors investigate a u03b2-cyclodextrin nanoparticle (CDNP) formulation encapsulating the Toll-like receptor 7 and 8 (TLR7/8) agonist R848 (CDNP-R848) to reprogram myeloid cells in the glioma microenvironment. The authors show that intravenous monotherapy with CDNP-R848 induces regression of established syngeneic experimental glioma, resulting in increased survival rates compared with unloaded CDNP controls. Mechanistically, the authors demonstrate . . .
  

   

  

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