T cell-intrinsic vitamin a metabolism and its signaling are targets for memory t cell-based cancer immunotherapy

HIGHLIGHTS

• who: Fumihiro Fujiki from the Care and Use Committee of Osaka University Graduate SchoolJackson Laboratory, United States have published the research: T Cell-Intrinsic Vitamin A Metabolism and Its Signaling Are Targets for Memory T Cell-Based Cancer Immunotherapy, in the Journal: (JOURNAL)
• how: The authors describe that T_cell itself can metabolize vitamin A into RAL by RDH10 a rate-limiting enzyme for RA biosynthesis and that lack of the vitamin A metabolism by Tcell-specific Rdh10 knockout enhances the induction of memory especially central memory T_cells (TCM) in Listeria infection model indicating that vitamin . . .
  

   

  

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