T cell receptor β-chain-targeting chimeric antigen receptor t cells against t cell malignancies

HIGHLIGHTS

  • who: Fanlin Li from the Academy of Sciences), cells were kindly provided by Dr. Justin Kline (University of Chicago)., OVA cells were kindly provided by Dr. Hans Schreiber (University of Chicago). Human peripheral blood mononuclear cells (PBMCs) were purchased from Allcells Biotechnology, Limited (Shanghai, China) or provided by Shanghai Longyao Biotechnology Limited. Informed written consent was obtained from all study participants, and the protocol was approved by the Suqian Obstetrics and Gynecology Hospital Ethics Committee. To generate Lenti-X, Vu03b28+ or Raji-Vu03b28+ cells, Lenti-X , or Raji cells were transduced with a lentivirus that expressed human . . .

     

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