T cell-specific constitutive active shp2 enhances t cell memory formation and reduces t cell activation

HIGHLIGHTS

• who: Clemens Cammann from the Ben-Gurion University of the Negev, McGill University, Canada have published the article: T cell-specific constitutive active SHP2 enhances T cell memory formation and reduces T cell activation, in the Journal: (JOURNAL)
• what: The authors demonstrated that the SHP2-D61Y mutation exclusively expressed in T_cells did not result in the onset of a proliferative disorder, whereas Ptpn11D61Y expression in mice with the Cre recombinase driven by the cd4 promoter led A B C Altered T_cell composition and reduced IFNg production in pTaSHP2mut mice.
• how: Similar observations were . . .
  

   

  

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