HIGHLIGHTS
- who: Vijay K. Singh from the (UNIVERSITY) have published the Article: Tackling recalcitrant Pseudomonas aeruginosa infections in critical illness via anti-virulence monotherapy, in the Journal: (JOURNAL) of 21/03/2022
- what: The authors show that MvfR promotes intestinal permeability and report potent antiMvfR compounds, the N-Aryl Malonamides (NAMs), resulting from extensive structure-activity-relationship studies and thorough assessment of the inhibition of MvfR-controlled virulence functions. This study shows the importance of MvfR in PA-driven intestinal permeability. Previously the authors focused on the family of compounds containing a benzothiazole moiety and a . . .
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