HIGHLIGHTS
- who: Shuqian Zhang from the (UNIVERSITY) have published the research work: TadA orthologs enable both cytosine and adenine editing of base editors, in the Journal: (JOURNAL) of 19/08/2022
- what: The authors show that in combined with an internal fusion strategy, functional base editors, including ABEs, CBEs, and ACBEs, are generated with various TadA orthologs containing just one or two amino_acid substitutions. This study provides an alternative and simplified strategy for orthologous TadA screening and engineering, which would be valuable for the expansion and diversification of base editing tools, and also provide insights into . . .
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