Tailoring mathematical models to stem-cell derived cardiomyocyte lines can improve predictions of drug-induced changes to their electrophysiology

HIGHLIGHTS

• who: Liudmila Polonchuk from the University of California, Davis, United States have published the Article: Tailoring Mathematical Models to Stem-Cell Derived Cardiomyocyte Lines Can Improve Predictions of Drug-Induced Changes to Their Electrophysiology, in the Journal: (JOURNAL)
• what: The authors focused on the maximum conductances of INa, ICaL, IKs, INaCa. The authors compared novel measurements in Cor.4U iPSC-CMs with predictions from a model based on the iCell cells. This study showed the need to build cell-line or even cellspecific models for iPSC-CMs, and this work serves as a pilot attempt . . .
  

   

  

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