Tailoring the structure of cell penetrating dna and rna binding nucleopeptides

HIGHLIGHTS

SUMMARY

The essential role of RNA and DNA in many physio-pathologic conditions justifies the intensive studies aimed to disclose the molecular basis of the interactions between nucleic_acids and their modulators. In this respect, the understanding that nucleic_acids are modulated through the interaction with other nucleic_acids and proteins paved the way for the development of synthetic nucleic_acid binders. Nucleic_acid-binding peptides, including cationic peptides, can bind DNA and RNA by electrostatic, hydrophobic, and hydrogen_bond interactions, forming high stable complexes. Both oligonucleotide analogues and nucleic_acid-binding peptides are affected by significant Int. The first exhibit poor . . .

 



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