HIGHLIGHTS
- who: Hong Wang and colleagues from the Minerva Foundation Institute for Medical Research, Helsinki, Finland Zebrafish Unit, HiLIFE and Department of Anatomy, University of Helsinki, Helsinki, Finland have published the Article: Tankyrase Inhibition Attenuates Cardiac Dilatation and Dysfunction in Ischemic Heart Failure, in the Journal: (JOURNAL)
- what: The authors demonstrate that pharmacological 17 of 25 inhibition of TNKS activity prevents cardiac dilatation and dysfunction in zebrafish, possibly through regulation of miRNA expression and suppression of Wnt/u03b2-catenin signaling via DICER and AXIN1, respectively.
- how: The authors explored the cardioprotective effect of TNKS . . .
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