HIGHLIGHTS
- who: Luke M. Simpson from the University of EH, UK have published the Article: Target protein localization and its impact on PROTAC-mediated degradation, in the Journal: (JOURNAL) of October/20,/2022
- what: Over the course of this study, a VHL-recruiting FKBP12F36V-directed PROTAC, dTAGV-1, was reported (Nabet et_al, 2020). Using this approach, more than 1,000 proteins were identified that had not yet been described in the literature as PROTAC targets, providing potential opportunities for future PROTAC-based therapies.
SUMMARY
By removing the POI, PROTACs abolish both enzymatic . . .
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