Targeted brd4 protein degradation by dbet1 ameliorates acute ischemic brain injury and improves functional outcomes associated with reduced neuroinflammation and oxidative stress and preservation of blood-brain barrier integrity

HIGHLIGHTS

  • who: Lei Liu from the Department of Neuroscience, McKnight Brain Institute, University of Florida, SW Newell Drive, Gainesville, FL, USA have published the article: Targeted BRD4 protein degradation by dBET1 ameliorates acute ischemic brain injury and improves functional outcomes associated with reduced neuroinflammation and oxidative stress and preservation of blood-brain barrier integrity, in the Journal: (JOURNAL)
  • what: This study provides several lines of evidence supporting dBET1 neuroprotection against ischemia-induced neurological deficits and brain damage through regulating inflammation and oxidative stress as well as preserving BBB integrity. dBET1 administration induced effective BRD4 degradation in . . .

     

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