Targeted inhibition of ubiquitin signaling reverses metabolic reprogramming and suppresses glioblastoma growth

HIGHLIGHTS

• who: Rossella Delle Donne from the University Federico II, Naples, Italy have published the paper: Targeted inhibition of ubiquitin signaling reverses metabolic reprogramming and suppresses glioblastoma growth, in the Journal: (JOURNAL) of July/21,/2017
• what: The authors report here the essential role of praja2 and UPS in the regulatory networks underlying the metabolic reprogramming of GBM cells. The analysis identified lysine 281 as a relevant ubiquitin acceptor site on KSR2 since its mutation to arginine significantly reduced KSR2 ubiquitylation in response to serum stimulation (Supplementary Fig 2b). Lysates were immunoblotted with anti-pThr172-AMPK . . .
  

   

  

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