Targeted protein degradation: expanding the toolbox to restrain cancer drug resistance

HIGHLIGHTS

• who: Hui Ming from the State Key Laboratory of Biotherapy and Center, West China, Sichuan University, and Collaborative Innovation Center have published the research work: Targeted protein degradation: expanding the toolbox to restrain cancer drug resistance, in the Journal: (JOURNAL)
• what: In this review, the authors aim to systematically describe the molecular mechanisms between protein degradation and drug resistance, the regulatory mechanism between E3s/DUBs/chaperones and drug resistance-related proteins and their potential clinical application value. Unfortunately, the emergence of acquired resistance to BRAF inhibitors (BRAFi) was inevitable and is one of the main . . .
  

   

  

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