Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment

HIGHLIGHTS

• who: Adrianne Wallace-Povirk from the DepartmentState University have published the research: Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment, in the Journal: Scientific Reports Scientific Reports of 12/Nov/2021
• what: An important goal of the study was to explore the impact of 2, 3 or 4 doses of AGF94 upon the tumor microenvironment, including infiltrating lymphocytes accompanying its anti-tumor effects. This study explored the potential of the novel pyrrol pyrimidine antifolate AGF94 for . . .
  

   

  

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