HIGHLIGHTS
- who: Inger Lauritzen from the Institut de Pharmacologie Moléculaire et Cellulaire, CNRS-UMR7275, team Distalz», Université de Nice-Sophia-Antipolis, Sophia-Antipolis, France have published the article: Targeting γ-secretase triggers the selective enrichment of oligomeric APP-CTFs in brain extracellular vesicles from Alzheimer cell and mouse models, in the Journal: (JOURNAL) of 24/Nov/1986
- what: The authors demonstrate that γ-secretase inhibition also drastically increases exosomal APP-CTF levels reflected by a diffuse extracellular APP-CTF-associated immunostaining in C99-accumulating brain areas, an anatomical observation that was supported by further biochemical analysis.
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