HIGHLIGHTS
- who: Lisa Pfitzer from the (UNIVERSITY) have published the Article: Targeting actin inhibits repair of doxorubicin-induced DNA damage: a novel therapeutic approach for combination therapy, in the Journal: (JOURNAL)
- what: On the cellular level the authors demonstrate that actin binders inhibit distinctive double strand break (DSB) repair pathways. The authors show that combination of subtoxic doses of actin-binding substances with classical chemotherapy is possible and leads to synergistic effects on tumor growth in_vivo. The authors demonstrate the failure of DSB repair due to actin manipulation after Doxo-induced DNA damage, both in_vitro and . . .
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