Targeting c/ebpα overcomes primary resistance and improves the efficacy of flt3 inhibitors in acute myeloid leukaemia

HIGHLIGHTS

• who: Hanlin Wang from the (UNIVERSITY) have published the Article: Targeting C/EBPu03b1 overcomes primary resistance and improves the efficacy of FLT3 inhibitors in acute myeloid leukaemia, in the Journal: (JOURNAL) of 13/03/2023
• what: Repurposed drugs targeting C/EBPu03b1 enhance FLT3i efficacy Considering that C/EBPu03b1 activation enhances FLT3i resistance (Figs 2 and 3) and that inactivation of C/EBPu03b1 enhances FLT3i sensitivity (Figs 4-7), the authors reason that targeting C/EBPu03b1 and its regulated gene network may be a viable approach for enhancing FLT3i sensitivity and overcoming FLT3i PR. The authors . . .
  

   

  

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