Targeting carbohydrate mimetics of tetrahydrofuran-containing acetogenins to prostate cancer

HIGHLIGHTS

• who: Patricia Gonzalez Periche and colleagues from the Department of Chemistry, Hunter College and The Graduate Center, City University of New York, New York, NY, USA have published the research work: Targeting Carbohydrate Mimetics of Tetrahydrofuran-Containing Acetogenins to Prostate Cancer, in the Journal: Molecules 2023, 28, 2884. of /2023/
• what: Two prodrugs comprising carbohydrate mimetics of mono-THF-containing acetogenins conjugated via a self-immolative linker to a ligand for PSMA, were prepared.
• how: For this preliminary study the authors employed an established methodology using 2-[3-(13-dicarboxypropyl)ureido] pentanedioic acid . . .
  

   

  

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