Targeting costimulatory pathways in systemic sclerosis

HIGHLIGHTS

• who: Jérôme Avouac from the Dresden University of Technology, Germany have published the article: Targeting Costimulatory Pathways in Systemic Sclerosis, in the Journal: (JOURNAL)
• what: There is a large body of evidence showing that T_cell costimulatory pathways play a critical role in the pathogenesis of SSc.

SUMMARY

Frontiers in Immunology | www.frontiersin.org December 2018 | Volume 9 | Article 2998 Costimulatory Pathways and SSc OX40 and its binding partner, OX40L are members of the TNF receptor superfamily and generate a potent costimulatory signal that upregulates IL-2 production, enhances T_cell . . .

 



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