Targeting eif4f translation initiation complex with sbi-756 sensitises b lymphoma cells to venetoclax

HIGHLIGHTS

• who: Lee-or Herzog from the DepartmentUniversity of Seattle, WA, USA have published the research work: Targeting eIF4F translation initiation complex with SBI-756 sensitises B lymphoma cells to venetoclax, in the Journal: (JOURNAL) of 30/09/2020
• what: The authors report experiments showing great potential for sensitisation of NHL cells to venetoclax via combination with SBI-756, a potent inhibitor of capdependent translation that is active in cells in the 100-500 nM range.
• future: Experiments are needed to determine whether cells with high eIF4E or eIF4G1 retain sensitivity to SBI-756 . . .
  

   

  

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