Targeting fatty acid synthase modulates sensitivity of hepatocellular carcinoma to sorafenib via ferroptosis

HIGHLIGHTS

  • who: Yan Li from the Department of Gastroenterology, Shanghai Tenth People`s Hospital, Tongji University School of Medicine, Shanghai, China have published the research: Targeting fatty acid synthase modulates sensitivity of hepatocellular carcinoma to sorafenib via ferroptosis, in the Journal: (JOURNAL)
  • what: This study aimed to explore the association of_(FASN) with sorafenib resistance via regulation of ferroptosis and provide a novel treatment strategy to overcome the sorafenib resistance of HCC patients. Both in vitro and in vivo studies were conducted to examine the antitumor effects of the combination of orlistat and sorafenib and CalcuSyn . . .

     

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