Targeting histone deacetylase 3 (hdac3) in the bone marrow microenvironment inhibits multiple myeloma proliferation by modulating exosomes and il-6 trans-signaling

HIGHLIGHTS

• who: Matthew Ho from the Department of Chemical Engineering, University of Massachusetts Lowell, One University Lowell, MA, USA have published the article: Targeting histone deacetylase 3 (HDAC3) in the bone marrow microenvironment inhibits multiple myeloma proliferation by modulating exosomes and IL-6 trans-signaling, in the Journal: (JOURNAL)
• what: The authors investigate the effects of HDAC3 targeting in BMSCs. Using both BMSC lines as well as patient-derived BMSCs the authors show that HDAC3 expression in BMSCs can be induced by co-culture with MM cells. The authors show that HDAC3-KD in BM endothelial . . .
  

   

  

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