Targeting hsp90 as a novel therapy for cancer: mechanistic insights and translational relevance

HIGHLIGHTS

• who: Jian Zhang and colleagues from the Institute of Thoracic Oncology and Department of Thoracic Surgery, West China Hospital of Sichuan University, Chengdu, China have published the paper: Targeting HSP90 as a Novel Therapy for Cancer: Mechanistic Insights and Translational Relevance, in the Journal: Cells 2022, 11, 2778. of /2022/

SUMMARY

The structure of HSP90 comprises three domains: the N-terminal domain (NTD) with ATPase activity, the middle domain (MD) that binds to the client protein, and the primary dimerization C-terminal domain (CTD). Separately, the co-chaperones that inhibit the ATPase activity . . .

 



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