Targeting janus kinase 3 in mast cells prevents immediate hypersensitivity reactions and anaphylaxis*

HIGHLIGHTS

• who: Ravi Malaviya from the evidence supporting the therapeutic potential of PTK inhibitors in the treatment of allergic disordersBecause of its in vivo potency and lack of systemic toxicity, the JAK3-specific PTK inhibitor WHI-, may offer the basis for new and effective treatment as well as prevention programs for mast cell-mediated hypersensitivity reactions in clinical settings. Acknowledgments-We gratefully acknowledge Dr. Christopher Navara of the Imaging Facility of the Hughes Institute for confocal microscopy of mast cells, Dr. Xing-Ping Liu from the Chemistry Department of the Hughes Institute for providing WHI compounds, and Dr . . .
  

   

  

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