Targeting key signaling pathways in glioblastoma stem cells for the development of efficient chemo- and immunotherapy

HIGHLIGHTS

  • who: Laureen P. Helweg and collaborators from the Department of Cell Biology, University of Bielefeld, Universitu00e4tsstrasse, Bielefeld, Germany have published the paper: Targeting Key Signaling Pathways in Glioblastoma Stem Cells for the Development of Efficient Chemo- and Immunotherapy, in the Journal: (JOURNAL)
  • what: The authors assessed the signaling of NF-u03baB and MYC with potential therapeutic applications in primary cancer stem_cells (CSCs) isolated from GBM. As a basis for new therapeutic strategies, the authors show that pharmacologic inhibition of NF-u03baB by ammonium pyrrolidine dithiocarbamate (PDTC) or inhibition of MYC/Myc-associated 3 of 24 . . .

     

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