HIGHLIGHTS
SUMMARY
Indeed, the accumulation of senescent cells can lead to disruption of tissue functionality, and limit the regenerative potential of adult stem_cells by damaging the stem_cell niches within the affected tissue. CoQ10 supplementation could have beneficial effects also against the development of cellular senescence, as demonstrated in mesenchymal stem_cells and H2 O2 -induced senescent HUVECs. Besides, ROS are also essential for stem_cell differentiation, as observed in different in_vivo models: murine hematopoietic stem_cells in a mouse model with reduced ROS levels because lacking AKT1 and AKT2 showed compromised differentiation, while in Drosophila hematopoietic progenitors, increasing ROS . . .
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