Targeting mitochondrial dna polymerase gamma for selective inhibition of mlh1 deficient colon cancer growth

HIGHLIGHTS

• who: Berna Somuncu and colleagues from the Editor: WSobol, University of South Istanbul, Turkey have published the Article: Targeting mitochondrial DNA polymerase gamma for selective inhibition of MLH1 deficient colon cancer growth, in the Journal: PLOS ONE of 28/04/2022
• what: The authors demonstrate that CR has a strong, concentrationdependent inhibitory effect on both the strand displacement and 1-nt incorporation activities of the Pol u03b3 enzyme.
• how: In this experiment the authors used the CR concentration (20 u03bcM) that affects the cell proliferation of HCT116V1 (Fig 4B) to see its effects . . .
  

   

  

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