HIGHLIGHTS
- who: Kate Brown and colleagues from the Georgetown University, United States have published the article: Targeting mutant p53-R248W reactivates WT p53 function and alters the onco-metabolic profile, in the Journal: (JOURNAL)
- what: Given the central effects of p53 on cellular metabolism, here the authors aim to investigate the effects of NSC59984 on mutant p53 and metabolism. As mutations at R248 seem to occur at a higher frequency in EAC (57 counts compared to 43 on the COSMIC database), the authors focused the research on this predominant population . This work has identified a distinctive . . .
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