HIGHLIGHTS
- who: Paula Olaizola from the Biodonostia Health Research Institute u2013 Donostia University Hospital, Paseo del DrSpain have published the research: Targeting NAE1-mediated protein hyper-NEDDylation halts cholangiocarcinogenesis and impacts on tumor-stroma crosstalk in experimental models, in the Journal: (JOURNAL)
- what: The study provides strong evidence that the expression levels of core NEDDylation pathway components are upregulated in human CCA tissue and cells compared to respective controls.
- how: The pro-tumorigenic effects of the secretome of CAFs seem to be independent of the NEDDylation status of CCA cells as similar proliferation and . . .
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