HIGHLIGHTS
- who: Maria J. Donde from the InstitutUniversity of Cambridge, Cambridge, UK have published the research: Targeting non-coding RNA family members with artificial endonuclease XNAzymes, in the Journal: (JOURNAL) of 13/09/2022
- what: The authors explore the potential of XNAzymes to provide highly specific molecular tools for knockdown of disease-associated noncoding RNA. The authors demonstrate that in contrast with previous oligonucleotide catalysts the resulting XNAzymes have the capacity to efficiently cleave noncoding RNAs under quasi-physiological conditions. Starting from a previously-described RNA endonuclease XNAzyme FR6_165 the authors demonstrate that a variety of . . .
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