Targeting nrf2 sensitizes esophageal adenocarcinoma cells to cisplatin through induction of ferroptosis and apoptosis

HIGHLIGHTS

  • who: Farah Ballout and colleagues from the Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA have published the research work: Targeting NRF2 Sensitizes Esophageal Adenocarcinoma Cells to Cisplatin through Induction of Ferroptosis and Apoptosis, in the Journal: Antioxidants 2022, 1859 of 10/05/2022
  • what: The authors investigated the role of NRF2 in Barrett`s related esophageal adenocarcinoma and determined the potential therapeutic efficacy of targeting NRF2 using Brusatol as a single agent and in combination with cisplatin. In the experiments , the authors utilized relatively low doses and demonstrated the . . .

     

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