HIGHLIGHTS
- who: August and colleagues from the Universidad de la República, Uruguay have published the article: Targeting of the intracellular redox balance by metal complexes towards anticancer therapy, in the Journal: (JOURNAL)
- what: This approach has been successfully demonstrated with RDC11 and RDC34 which were able to strongly induce CHOP, a transcription factor that mediates apoptosis in response to ER stress (Meng et_al, 2009).
- how: Such results showed that the modification of the spatial structure of the complexes may also be responsible for their capacity to alter the redox enzyme function (Anand et_al . . .
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