Targeting oxidative phosphorylation with a mitochondrial complex i inhibitor is limited by mechanism-based toxicity

HIGHLIGHTS

  • who: Posted Date April and colleagues from the The University of Texas MD Cancer Center https://orcidorg/0000-0002-9347, have published the research work: Targeting Oxidative Phosphorylation with a Mitochondrial Complex I Inhibitor is limited by Mechanism-based Toxicity, in the Journal: (JOURNAL) of April/10,/2019
  • what: All authors can confirm the accuracy and completeness of the study . The aim of the AML and Solid Tumor Trial was to determine the safety, tolerability, maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D) of IACS-010759.
  • how: The previous in_vitro data . . .

     

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