HIGHLIGHTS
- who: Xu Han and colleagues from the Feinberg School Northwestern University IL, USA have published the research work: Targeting pleckstrin-2-Akt signaling reduces proliferation in myeloproliferative neoplasm models, in the Journal: (JOURNAL)
- what: The authors aimed to reveal the mechanism of Plek2 in MPN pathogenesis and identify small_molecule compounds that target Plek2 and block its functions in MPNs. The recently published work using this model demonstrated that repeated injection of EPO rapidly induced erythrocytosis, splenomegaly, and moderate vascular occlusions in wild-type mice in three weeks(12). Before testing NUP-17d in this model . . .
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