Targeting sam-i riboswitch using antisense oligonucleotide technology for inhibiting the growth of staphylococcus aureus and listeria monocytogenes

HIGHLIGHTS

  • who: Martina Traykovska and Robert Penchovsky from the Department of Genetics, Faculty of Biology, University StKliment Ohridski, Dragan Tzankov Blvd have published the article: Targeting SAM-I Riboswitch Using Antisense Oligonucleotide Technology for Inhibiting the Growth of Staphylococcus aureus and Listeria monocytogenes, in the Journal: Antibiotics 2022, 11, 1662. of 19/Nov/2022
  • what: This paper demonstrates the specific inhibition of the SAM-I riboswitch mRNA by pVEC-ASO-1, leading to the growth inhibition of S. aureus and L monocytogenes.
  • how: The pVEC-ASO toxicity was tested in a human cell line . . .

     

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