HIGHLIGHTS
- who: Yundong He from the (UNIVERSITY) have published the Article: Targeting signaling pathways in prostate cancer: mechanisms and clinical trials, in the Journal: (JOURNAL) of 12/03/2022
- what: Overexpression of EZH2, a histone methyltransferase, is a major reason for the increased genomic distribution of H3K27me3 in metastatic PCa.409 EZH2 plays an important role in promoting lineage plasticity and differentiation changes, which are highly associated with NEPC .
- future: The clinical application of PI3K/AKT/mTOR inhibitors is still limited in PCa and further studies that can identify new biomarkers for patient selection . . .
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