Targeting sphingosine kinase 1/2 by a novel dual inhibitor ski-349 suppresses non-small cell lung cancer cell growth

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• who: Yuhang Xue from the The fluorescence dyes utilized in the study were described previously [21, ]Annexin, propidium iodide (PI) FACS (fluorescence-activated cell sorting) kit was purchased from Thermo-Fisher Invitrogen Co. (Shanghai, China). Antibodies for Sph, (#32346), (bromodomain-containing protein, #13440), p-JNK1/, (Thr183/Tyr185, #4671) and , antibody (#3708) were purchased from Cell Signaling Technologies (Beverly, MA). Antibodies for tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL, #3219), cytochrome c (Cyto-C, #4280), cathepsin B (#31718), cathepsin D (#69854), Bax (#89477) were from Signaling Tech. The anti-tBid was provided by Abcam (ab10640). Other . . .
  

   

  

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