Targeting the bet-hedging strategy with an inhibitor of bacterial efflux capacity enhances antibiotic efficiency and ameliorates bacterial persistence in vitro

HIGHLIGHTS

  • who: Demosthenes Morales et al. from the Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM, USA Institute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, NY, USA have published the paper: Targeting the Bet-Hedging Strategy with an Inhibitor of Bacterial Efflux Capacity Enhances Antibiotic Efficiency and Ameliorates Bacterial Persistence In Vitro, in the Journal: Microorganisms 2022, 1966 of /2022/
  • what: The authors demonstrated that a synthetic non-toxic taxane-based reversal agent (tRA) developed as an inhibitor of ABC transporter systems in mammalian cancer cells enhanced antibiotic killing of persister . . .

     

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