Targeting the corest complex with dual histone deacetylase and demethylase inhibitors

HIGHLIGHTS

• who: Jay H. Kalin from the (UNIVERSITY) have published the paper: Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: In the assays , the authors did not observe significant inhibition of LSD1 with 4SC-202 (Supplementary Fig 2) so it would appear to have a different mechanism of action from the inhibitors the authors report here (see below).
• future: Computational modeling of the subunit proteins suggests the plausibility of energetically stable conformations with surface loop changes that allow for dual occupancy of LSD1 . . .
  

   

  

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