Targeting the retinoblastoma/e2f repressive complex by cdk4/6 inhibitors amplifies oncolytic potency of an oncolytic adenovirus

HIGHLIGHTS

• who: Jana Koch from the (UNIVERSITY) have published the article: Targeting the Retinoblastoma/E2F repressive complex by CDK4/6 inhibitors amplifies oncolytic potency of an oncolytic adenovirus, in the Journal: (JOURNAL) of 28/05/2021
• what: The authors show that in combination CDK4/6 inhibitors potentiate the anti-tumor effect of the oncolytic adenovirus XVir-N-31 in bladder cancer and murine Ewing sarcoma xenograft models. It is important to note that these assays also demonstrate that transcription of E2-early genes in the context of the viral genome are controlled by additional factors since . . .
  

   

  

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